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GOLPH3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 191121AP

Catalog No. 50-173-2344


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Description

Description

GOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but others reported it to be primarily a mitochondrial protein that regulated the mitochondrial mass through the regulation of the mitochondria-specific phospholipid cardiolipin. GOLPH3 has since been implicated in the target of rapamycin (TOR) signalling pathway. Its overexpression in transfected cells led to and increase in anchorage-independent growth and cell proliferation in vitro. Furthermore, GOLPH3-transfected cells enhanced S6 Kinase activity in response to growth factor stimulation by EGF. Simultaneously, AKT phosphorylation increased in these cells, while these events were abrogated in GOLPH3 siRNA treated cells compared to control cells, indicating the GOLPH3 can enhance signalling through TOR-associated complexes. These results suggest that GOLPH3 is a bona fide oncogene and may be a useful target for therapeutic strategies.
Specifications

Specifications

GOLPH3
0.33 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q9CRA5, Q9ERE4, Q9H4A6
Coat protein GPP34, Golgi phosphoprotein 3, GOLPH3, GOPP1, GPP34, MIDAS
Rabbit
IgG
150 μL
-20°C
Primary
64083, 66629, 78961
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
GOLPH3
Liquid
GOLPH3
GOLPH3 Fusion Protein Ag5443
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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