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GP2 Antibody (GP2/1803), Alexa Fluor™ 488, Novus Biologicals™
SDP

Catalog No. NB009180 Shop All R&D Systems Products
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NB009180 0.1 mL
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Catalog No. NB009180 Supplier Novus Biologicals Supplier No. NBP275781AF488
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Mouse Monoclonal Antibody

GP2 Monoclonal specifically detects GP2 in Human samples. It is validated for Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen GP2
Applications ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone GP2/1803
Conjugate Alexa Fluor 488
Dilution ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias DKFZp779K0533, glycoprotein 2 (zymogen granule membrane), pancreatic secretory granule membrane major glycoprotein GP2, pancreatic zymogen granule membrane associated protein GP2, Pancreatic zymogen granule membrane protein GP-2, ZAP75
Gene Symbols GP2
Host Species Mouse
Immunogen Recombinant fragment of human GP2 protein (around aa 35-179) (exact sequence is proprietary) (Uniprot: P55259)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG2a κ
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