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Invitrogen™ GP6 Polyclonal Antibody
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Catalog No. PIPA5111615
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100 μL
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PIPA5111615 100 μL
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Catalog No. PIPA5111615 Supplier Invitrogen™ Supplier No. PA5111615
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VTLRCQGPPG VDLYRLEKLS SSRYQDQAVL FIPAMKRSLA GRYRCSYQNG SLWSLPSDQL Highest antigen sequence indentity to the following orthologs: Mouse - 78%, Rat - 65%.

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GP6
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GP6
Gene Accession No. Q9HCN6
Gene Alias 9830166G18Rik; BDPLT11; Glycoprotein 5; glycoprotein 6; glycoprotein 6 (platelet); glycoprotein VI (platelet); glycoprotein VI platelet; Gm469; GP6; GPIV; GPVI; platelet collagen receptor; platelet glycoprotein VI
Gene Symbols GP6
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human GP6. Recombinant protein control fragment (Product #RP-103633).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51206
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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