Invitrogen™ GPAM Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA561218

Catalog No. PIPA561218

Description

Immunogen sequence: INETHTRHRG WLARRLSYVL FIQERDVHKG MFATNVTENV LNSSRVQEAI AEVAAELNPD GSAQQQSKAV NKVKKKAKRI LQ Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 88%.

Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.

Specifications

• Antigen: GPAM
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gpam
• Gene Alias: glycerol 3-phosphate acyltransferase, mitochondrial; glycerol-3-phosphate acyltransferase 1, mitochondrial; glycerol-3-phosphate acyltransferase, mitochondrial; GPAM; GPAT; GPAT1; GPAT-1; KIAA1560; P90; RP11-426E5.2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57678
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.10 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9HCL2
• Gene Symbols: Gpam
• Immunogen: Recombinant protein corresponding to Human GPAM. Recombinant protein control fragment (Product #RP-97073).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG