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Invitrogen™ GPAM Polyclonal Antibody
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Catalog No. PIPA561218
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100 μL
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PIPA561218 100 μL
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Catalog No. PIPA561218 Supplier Invitrogen™ Supplier No. PA561218
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: INETHTRHRG WLARRLSYVL FIQERDVHKG MFATNVTENV LNSSRVQEAI AEVAAELNPD GSAQQQSKAV NKVKKKAKRI LQ Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 88%.

Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GPAM
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Gpam
Gene Accession No. Q9HCL2
Gene Alias glycerol 3-phosphate acyltransferase, mitochondrial; glycerol-3-phosphate acyltransferase 1, mitochondrial; glycerol-3-phosphate acyltransferase, mitochondrial; GPAM; GPAT; GPAT1; GPAT-1; KIAA1560; P90; RP11-426E5.2
Gene Symbols Gpam
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GPAM. Recombinant protein control fragment (Product #RP-97073).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57678
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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