Invitrogen™ GPAM Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA593092

Catalog No. PIPA593092

Description

Immunogen sequence: LNKRGLGGPT STPPNLISQE QLVRKAASLC YLLSNEGTIS LPCQTFYQVC HETVGKFIQY GILTVAEHDD QEDISPSLAE QQWDKKLPEP LSWRSDEEDE DSDFGEEQRD CYLKVSQSKE HQQFITFLQR LLGPLLEAYS SAAIFVHNFS GPVPEPEYLQ KLHKYLITRT ERNVAVYAES ATYCLVKNAV KMFKDIGVFK ETKQKRVSVL ELSSTFLPQC NRQKLLEYIL SFVVL; Positive Samples: Mouse heart, Mouse lung, Rat brain; Cellular Location: Mitochondrion outer membrane, Multi-pass membrane protein.

Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.

Specifications

• Antigen: GPAM
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gpam
• Gene Alias: glycerol 3-phosphate acyltransferase, mitochondrial; glycerol-3-phosphate acyltransferase 1, mitochondrial; glycerol-3-phosphate acyltransferase, mitochondrial; GPAM; GPAT; GPAT1; GPAT-1; KIAA1560; P90; RP11-426E5.2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14732, 29653, 57678
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.45 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P97564, Q61586, Q9HCL2
• Gene Symbols: Gpam
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 594-828 of human GPAM (NP_0012318781).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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