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Invitrogen™ GPLD1 Polyclonal Antibody
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Catalog No. PIPA552941
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100 μL
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PIPA552941 100 μL
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Catalog No. PIPA552941 Supplier Invitrogen™ Supplier No. PA552941
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FWSTNIYHLT SFMLENGTSD CNLPENPLFI ACGGQQNHTQ GSKMQKNDFH RNLTTSLTES VDRNINYTER GVFFSVNSWT PDSMSFIYKA LERNIRTMFI GGSQLSQKHV SS Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 68%.

GPLD1 is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. Liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPLD1 in the serum. GPLD1 is abundant in serum in which it associates with polipoproteins AI and AIV. Increased serum GPLD1 is associated with insulin resistance and elevated serum triglycerides. Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein and cleavage of the GPI moiety by GPLD1, only enzyme known that cleavage GPI anchor, may represent a means of regulating attachment of these proteins to the cell surface, or alternatively, their release into the extracellular environment.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GPLD1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GPLD1
Gene Accession No. P80108
Gene Alias 6330541J12Rik; AW546131; glycoprotein phospholipase D; glycosylphosphatidylinositol phospholipase D; glycosylphosphatidylinositol specific phospholipase D1; glycosylphosphatidylinositol specific phospholipase D1, isoform 2; Glycosyl-phosphatidylinositol-specific phospholipase D; GPIPLD; GPI-PLD; GPIPLDM; GPI-specific phospholipase D; Gpld1; MGC22590; Phosphatidylinositol-glycan-specific phospholipase D; PI-G PLD; PIGPLD; PIGPLD1; PLD
Gene Symbols GPLD1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GPLD1. Recombinant protein control fragment (Product #RP-102400).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2822
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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