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Invitrogen™ GPLD1 Polyclonal Antibody
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Catalog No. PIPA5121014
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100 μL
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PIPA5121014 100 μL
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Catalog No. PIPA5121014 Supplier Invitrogen™ Supplier No. PA5121014
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Description

Rabbit Polyclonal Antibody

Positive test controls include: Human plasma, Mouse plasma, Mouse liver, Rat plasma. The target is usually found in the following locations: Secreted. Immunogen sequence: CGLSTHVEIG HRALEFLQLH NGRVNYRELL LEHQDAYQAG IVFPDCFYPS ICKGGKFHDV SESTHWTPFL NASVHYIREN YPLPWEKDTE KLVAFLFGIT SHMAADVSWH SLGLEQGFLR TMGAIDFHGS YSEAHSA.

GPLD1 is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. Liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPLD1 in the serum. GPLD1 is abundant in serum in which it associates with polipoproteins AI and AIV. Increased serum GPLD1 is associated with insulin resistance and elevated serum triglycerides. Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein and cleavage of the GPI moiety by GPLD1, only enzyme known that cleavage GPI anchor, may represent a means of regulating attachment of these proteins to the cell surface, or alternatively, their release into the extracellular environment.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GPLD1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.75 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene GPLD1
Gene Accession No. O70362, P80108, Q8R2H5
Gene Alias 6330541J12Rik; AW546131; glycoprotein phospholipase D; glycosylphosphatidylinositol phospholipase D; glycosylphosphatidylinositol specific phospholipase D1; glycosylphosphatidylinositol specific phospholipase D1, isoform 2; Glycosyl-phosphatidylinositol-specific phospholipase D; GPIPLD; GPI-PLD; GPIPLDM; GPI-specific phospholipase D; Gpld1; MGC22590; Phosphatidylinositol-glycan-specific phospholipase D; PI-G PLD; PIGPLD; PIGPLD1; PLD
Gene Symbols GPLD1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 24-160 of human GPLD1 (NP_001494.2).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14756, 2822, 291132
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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