Invitrogen™ GPNMB Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589716

Catalog No. PIPA589716

Description

Positive Samples: A-549, K-562, U-87MG, Mouse brain, Mouse liver, Rat brain, Rat liver; Cellular Location: Cell membrane, Melanosome, Single-pass type I membrane protein Immunogen sequence: KRFHDVLGNE RPSAYMREHN QLNGWSSDEN DWNEKLYPVW KRGDMRWKNS WKGGRVQAVL TSDSPALVGS NITFAVNLIF PRCQKEDANG NIVYEKNCRN EAGLSADPYV YNWTAWSEDS DGENGTGQSH HNVFPDGKPF PHHPGWRRWN FIYVFHTLGQ YFQKLGRCSV RVSVNTANVT LGPQLMEVTV YRRHGRAYVP IAQVKDVYVV TDQIPVFVTM FQKNDRNSSD ETFLKDLPIM FDVLIHDPSH FLNYSTINYK WSFGDNTGLF VSTNHTVNHT YVLNGTFSLN LTVKAAAPGP CPPPPPPPRP SKPTPSLATT LKSYDSNTPG PAGDNPLELS RIPDENCQIN RYGHFQATIT IVEGILEVNI IQMTDVLMPV PWPESSLIDF VVTCQGSIPT EVCTIISDPT CEITQNTVCS PVDVDEMCLL TVRRTFNGSG TYCVNLTLGD DTSLALTSTL ISVP.

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: GPNMB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GPNMB
• Gene Alias: Dchil; DC-HIL; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; dendritic cell-associated transmembrane protein; glycoprotein (transmembrane) nmb; glycoprotein nmb; glycoprotein nmb-like protein; glycoprotein nonmetastatic melanoma protein B; Gpnmb; hematopoietic growth factor inducible neurokinin-1; Hematopoietic growth factor inducible neurokinin-1 type; Hgfin; ipd; iris pigment dispersion; NMB; Osteoactivin; si:ch211-155k24.6; transmembrane glycoprotein HGFIN; transmembrane glycoprotein NMB; Unknown (protein for MGC:133733); UNQ1725/PRO9925
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10457, 113955, 93695
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.85 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q14956, Q6P7C7, Q99P91
• Gene Symbols: GPNMB
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 23-486 of human GPNMB (NP_0010053401).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG