Invitrogen™ GPNMB Recombinant Rabbit Monoclonal Antibody (105)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA530474

Catalog No. PIMA530474

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. This antibody has specificity for Human GPNMB/Osteoactivin.

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: GPNMB
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q14956
• Gene Symbols: GPNMB
• Immunogen: Recombinant Human GPNMB/Osteoactivin Protein (Met1-Pro474).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA
• Clone: 105
• Conjugate: Unconjugated
• Gene: GPNMB
• Gene Alias: Dchil; DC-HIL; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; dendritic cell-associated transmembrane protein; glycoprotein (transmembrane) nmb; glycoprotein nmb; glycoprotein nmb-like protein; glycoprotein nonmetastatic melanoma protein B; Gpnmb; hematopoietic growth factor inducible neurokinin-1; Hematopoietic growth factor inducible neurokinin-1 type; Hgfin; ipd; iris pigment dispersion; NMB; Osteoactivin; si:ch211-155k24.6; transmembrane glycoprotein HGFIN; transmembrane glycoprotein NMB; Unknown (protein for MGC:133733); UNQ1725/PRO9925
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 10457
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid