Invitrogen™ GPR112 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA557228

Catalog No. PIPA557228

Description

Immunogen sequence: INTGKSQWEK PKFKQCKLLQ ELPDKIVDLA NITISDENAE DVAEHILNLI NESPALGKEE TKIIVSKISD ISQCDEISMN LTHVMLQIIN VVLEKQ Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 27%.

G protein-coupled receptors(GPRs or GPCRs), also known asseven transmembrane receptors, heptahelical receptors or 7TMreceptors, aremembers of the largest protein family and play a role in many differentstimulus-response pathways. G protein-coupled receptors mediate extracellularsignals into intracellularsignals(G protein activation). Theyrespond to awide variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GPR proteins are usuallyintegralseven passmembrane proteins with some conserved amino acid regions. GPR112 (G protein-coupled receptor 112) is a 3,080 amino acid multi-pass membrane protein that belongsto the G-protein coupled receptor 2 family and LN-TM7 subfamily. Localizing to cell membrane, GPR112 is highly expressed in normal enterochromaffin cells, aswell as neuroendocrine and primarylivercarcinoma. GPR112 contains one GPS domain andmayfunction as an orphan receptor.

Specifications

• Antigen: GPR112
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ADGRG4
• Gene Alias: ADGRG4; adhesion G protein-coupled receptor G4; adhesion G-protein coupled receptor G4; G protein-coupled receptor 112; Gm367; GPR112; G-protein coupled receptor 112; PGR17; probable G-protein coupled receptor 112; RP1-299I16
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 139378
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IZF6
• Gene Symbols: ADGRG4
• Immunogen: Recombinant protein corresponding to Human GPR112. Recombinant protein control fragment (Product #RP-94997).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov