Invitrogen™ GPR125 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552626

Catalog No. PIPA552626

Description

Immunogen sequence: DIFRGLTNLV RLNLSGNLFS SLSQGTFDYL ASLRSLEFQT EYLLCDCNIL WMHRWVKEKN ITVRDTRCVY PKSLQAQPVT GVKQELLTCD PPLELPSFYM TPSHRQVVFE GDSLPFQCMA SYIDQDMQVL WYQDGRI Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.

G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR125 (G protein-coupled receptor 125), also known as PGR21 or TEM5L, is a 1,321 amino acid multi-pass membrane protein belonging to the G-protein coupled receptor 2 family and the LN-TM7 subfamily. Considered a novel orphan adhesion-type G-protein-coupled receptor, GPR125 has five leucine rich repeats (LRR), an immunoglobulin (Ig) domain and a GPS domain. GPR125 may play a functional role in choroidal and hippocampal response to brain injury. It is also suggested that GPR125 may be a marker for spermatogonial stem cells. Four isoforms of GPR125 exists due to alternative splicing events.

Specifications

• Antigen: GPR125
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ADGRA3
• Gene Alias: 3830613O22Rik; Adgra2; ADGRA3; adhesion G protein-coupled receptor A2; adhesion G protein-coupled receptor A3; AU044632; G protein-coupled receptor 125; Gpr125; G-protein coupled receptor 125; PGR21; probable G-protein coupled receptor 125; TEM5L; Tem5-like; UNQ556/PRO1113
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 166647
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IWK6
• Gene Symbols: ADGRA3
• Immunogen: Recombinant protein corresponding to Human GPR125. Recombinant protein control fragment (Product #RP-89573).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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