Invitrogen™ GPR125 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120377

Catalog No. PIPA5120377

Description

Positive test controls include: Mouse liver. The target is usually found in the following locations: Membrane, Multi-pass membrane protein. Immunogen sequence: ITAYLQCTRN THGSGIYPGN PQDERKAWRR CDRGGFWADD DYSRCQYAND VTRVLYMFNQ MPLNLTNAVA TARQLLAYTV EAANFSDKMD VIFVAEMIEK FGRFTKEEKS KELGDVMVDI ASNIMLADER VLWLAQREAK ACSRIVQCLQ RIATYRLAGG AHVYSTYSPN IALEAYVIKS TGFTGMTCTV FQKVAASDRT GLSDYGRRDP EGNLDKQLSF KCNVSNTFSS L.

G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR125 (G protein-coupled receptor 125), also known as PGR21 or TEM5L, is a 1,321 amino acid multi-pass membrane protein belonging to the G-protein coupled receptor 2 family and the LN-TM7 subfamily. Considered a novel orphan adhesion-type G-protein-coupled receptor, GPR125 has five leucine rich repeats (LRR), an immunoglobulin (Ig) domain and a GPS domain. GPR125 may play a functional role in choroidal and hippocampal response to brain injury. It is also suggested that GPR125 may be a marker for spermatogonial stem cells. Four isoforms of GPR125 exists due to alternative splicing events.

Specifications

• Antigen: GPR125
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ADGRA3
• Gene Alias: 3830613O22Rik; Adgra2; ADGRA3; adhesion G protein-coupled receptor A2; adhesion G protein-coupled receptor A3; AU044632; G protein-coupled receptor 125; Gpr125; G-protein coupled receptor 125; PGR21; probable G-protein coupled receptor 125; TEM5L; Tem5-like; UNQ556/PRO1113
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 305408, 70693
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.2 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q7TT36
• Gene Symbols: ADGRA3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 370-600 of human ADGRA3 (NP_660333.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG