GPR14 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-4169	100 μL

Catalog No. 50-198-4169 Supplier Bioss Supplier No. BS1806R

Description

Rabbit Polyclonal Antibody

The Urotensin-II receptor has been reported to be expressed at high levels in the heart and pancreas and also in artery and smooth muscle. Low transcript levels have been identified in brain, particularly in thalamus, and superior occipital gyrus. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: GPR14
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: UTS2R
• Gene Accession No.: Q9UKP6
• Gene Alias: G protein-coupled receptor 14; Gpr14; G-protein coupled receptor 14; G-protein coupled sensory epithelial neuropeptide-like receptor; putative G protein-coupled receptor (SENR); Senr; Uiir; Uii-r; Uii-r1a; UII-receptor; UR2R; UR-2-R; UR-II-R; urotensin 2 receptor; Urotensin II receptor; Urotensin-2 receptor; UT-II; UTIIR; UTR; UTR2; UTS2R
• Gene Symbols: UTS2R
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human UTS2R.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2837
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG