Invitrogen™ GPR160 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532806

Catalog No. PIPA532806

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (95%); Marmoset (85%); Rabbit (80%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

GPR160, part of the Class A family of G protein-coupled receptors (GPCRs), is prominently expressed in mouse embryonic stem cells and has been associated with various human solid tumors, particularly prostate cancer. The gene's expression contributes to the self-renewal and pluripotency of stem cells by participating in critical signaling pathways, including the JAK/STAT pathway, which is crucial for maintaining the stem cell cycle. High levels of GPR160 expression are observed in prostate cancer, though its role in disease progression is independent of the CARTp-mediated signaling pathway. Investigations into GPR160 have revealed its potential as a biomarker for prostate cancer. Additionally, it regulates mycobacteria entry into macrophages, implicating its functionality in immune responses. The gene's mechanisms of action, especially within cancer contexts, are subjects of ongoing research aimed at understanding its precise contributions to cellular proliferation and disease phenotypes.

Specifications

• Antigen: GPR160
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GPR160
• Gene Alias: 1700025D19Rik; G protein-coupled receptor 160; GPCR1; GPCR150; GPR160; G-protein coupled receptor GPCR1; hGPCR1; probable G-protein coupled receptor 160; putative G protein-coupled receptor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26996
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: Q9UJ42
• Gene Symbols: GPR160
• Immunogen: Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human GPR160.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG