Invitrogen™ GPR160 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA575327

Catalog No. PIPA575327

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

GPR160, part of the Class A family of G protein-coupled receptors (GPCRs), is prominently expressed in mouse embryonic stem cells and has been associated with various human solid tumors, particularly prostate cancer. The gene's expression contributes to the self-renewal and pluripotency of stem cells by participating in critical signaling pathways, including the JAK/STAT pathway, which is crucial for maintaining the stem cell cycle. High levels of GPR160 expression are observed in prostate cancer, though its role in disease progression is independent of the CARTp-mediated signaling pathway. Investigations into GPR160 have revealed its potential as a biomarker for prostate cancer. Additionally, it regulates mycobacteria entry into macrophages, implicating its functionality in immune responses. The gene's mechanisms of action, especially within cancer contexts, are subjects of ongoing research aimed at understanding its precise contributions to cellular proliferation and disease phenotypes.

Specifications

• Antigen: GPR160
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GPR160
• Gene Alias: 1700025D19Rik; G protein-coupled receptor 160; GPCR1; GPCR150; GPR160; G-protein coupled receptor GPCR1; hGPCR1; probable G-protein coupled receptor 160; putative G protein-coupled receptor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26996, 499588, 71862
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q3U3F9, Q66H29, Q9UJ42
• Gene Symbols: GPR160
• Immunogen: Synthetic peptide corresponding to amino acids 305-338 of Human GPR160.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG