GPR17 Mouse anti-Human, Clone: OTI10B8, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF811748

Catalog No. 50-167-0822

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR17 is an orphan G protein-coupled receptor involved in orchestration of oligodendrocyte differentiation and myelination in the central nervous system. GPR17 is expressed in brain, kidney, heart and umbilical vein endothelial cells. GPR17 has dual specificity for uracil nucleotides and cysteinyl leukotrienes and signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and cysteinyl leukotrienes following ischemia.

Specifications

• Antigen: GPR17
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: GPR17
• Gene Alias: G protein-coupled receptor 17
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2840
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin)
• Clone: OTI10B8
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q13304
• Gene Symbols: GPR17
• Immunogen: Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human GPR17 C-terminal. The exact sequence is proprietary.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1