Invitrogen™ GPR18 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532810

Catalog No. PIPA532810

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bat, Elephant, Horse, Rabbit, Pufferfish (100%); Mouse, Rat, Bovine, Pig, Opossum, Salmon, Zebrafish, Stickleback (94%); Chicken, Platypus, Lizard, Catfish (88%); Hamster, Turkey (81%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR18 is an orphan G protein-coupled receptor found at high levels in the testis, small intestines and cells associated with the immune system including lymphocytes, thymus and spleen. GPR18 has been found to be a receptor for endogenous lipid neurotransmitters, several of which also bind to cannabinoid receptors. Some ligands described to be GPR18 agonists or partial agonists include N-Arachidonoylglycine, Abnormal cannabidiol, O-1602, AM-251, Cannabidiol, delta 9-Tetrahydrocannabinol, N-arachidonoyl ethanolamine and Arachidonylcyclopropylamide. Antagonists include the synthetic cannabidiol related compounds CID-85469571 and O-1918.

Specifications

• Antigen: GPR18
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GPR18
• Gene Alias: EMBL:AAI28783.1}; G protein-coupled receptor 18; GPCRW; Gpr18; gpr18 {ECO:0000312; G-protein coupled receptor 18; NAGly receptor; N-arachidonyl glycine receptor; RP11-461N23.8
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100147633, 100357321, 2841
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: Q14330
• Gene Symbols: GPR18
• Immunogen: Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human GPR18.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Rabbit, Monkey, Horse, Bat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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