Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Invitrogen™ GPR182 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532811

Catalog No. PIPA532811


Only null left
Add to Cart

Description

Description

Percent identity with other species by BLAST analysis: Human (100%) Gorilla, Gibbon (94%).

Adrenomedullin (ADM) is a hypotensive peptide that belongs to a peptide superfamily, which includes the calcitonin gene-related peptide (CGRP) and amylin. ADM was originally identified in the adrenal medulla, where it is highly expressed. It is also produced by most contractile cells and is upregulated during sepsis and ischemia. Three distinct receptors have the ability to bind ADM and are designated ADM receptor (also designated L1), RDC-1 and the Calcitonin Receptor-Like Receptor (CRLR). The CRLR associates with receptor activity-modifying proteins (RAMPs), which determine the specificity of CRLR binding. Co-expression with RAMP1 results in CRLR binding to CGRP, whereas association with RAMP2 or 3 results in ADM binding. The ADM receptor, a seven transmembrane G protein-coupled receptor, specifically binds ADM and is highly expressed in heart, brain, skeletal muscle, the immune system, adrenal gland and liver. The ADM receptor mediates the signals produced by ADM through G proteins, which activate adenylate cyclase.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

GPR182
Polyclonal
Unconjugated
GPR182
7TMR; ADMR; adrenomedullin receptor; AMR; AM-R; G protein-coupled receptor 182; G10D; G10-D; gamrh; Gpcr17; Gpcr22; GPR182; G-protein coupled receptor 182; HAMR; hrhAMR; MB10; NOW; RAMR
Rabbit
Antigen affinity chromatography
RUO
11318
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin)
1.0 mg/mL
PBS with 0.1% sodium azide
O15218
GPR182
Synthetic 18 amino acid peptide from C-terminus of human GPR182 / ADMR.
50 μg
Primary
Human
Antibody
IgG
Product Suggestions

Product Suggestions

Videos
Safety and Handling

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.