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Invitrogen™ GPR182 Polyclonal Antibody
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Catalog No. PIPA532813
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50 μg
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PIPA532813 50 μg
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Catalog No. PIPA532813 Supplier Invitrogen™ Supplier No. PA532813
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Description

Rabbit Polyclonal Antibody

Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Gorilla, Monkey (94%); Marmoset (83%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Adrenomedullin (ADM) is a hypotensive peptide that belongs to a peptide superfamily, which includes the calcitonin gene-related peptide (CGRP) and amylin. ADM was originally identified in the adrenal medulla, where it is highly expressed. It is also produced by most contractile cells and is upregulated during sepsis and ischemia. Three distinct receptors have the ability to bind ADM and are designated ADM receptor (also designated L1), RDC-1 and the Calcitonin Receptor-Like Receptor (CRLR). The CRLR associates with receptor activity-modifying proteins (RAMPs), which determine the specificity of CRLR binding. Co-expression with RAMP1 results in CRLR binding to CGRP, whereas association with RAMP2 or 3 results in ADM binding. The ADM receptor, a seven transmembrane G protein-coupled receptor, specifically binds ADM and is highly expressed in heart, brain, skeletal muscle, the immune system, adrenal gland and liver. The ADM receptor mediates the signals produced by ADM through G proteins, which activate adenylate cyclase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GPR182
Applications ELISA, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene GPR182
Gene Accession No. O15218
Gene Alias 7TMR; ADMR; adrenomedullin receptor; AMR; AM-R; G protein-coupled receptor 182; G10D; G10-D; gamrh; Gpcr17; Gpcr22; GPR182; G-protein coupled receptor 182; HAMR; hrhAMR; MB10; NOW; RAMR
Gene Symbols GPR182
Host Species Rabbit
Immunogen Synthetic 18 amino acid peptide from C-terminus of human GPR182 / ADMR.
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11318
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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