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Invitrogen™ GPR182 Polyclonal Antibody
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Catalog No. PA550627
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PA550627 100 μL
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Catalog No. PA550627 Supplier Invitrogen™ Supplier No. PA550627
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total GPR182 / ADMR protein.

Adrenomedullin (ADM) is a hypotensive peptide that belongs to a peptide superfamily, which includes the calcitonin gene-related peptide (CGRP) and amylin. ADM was originally identified in the adrenal medulla, where it is highly expressed. It is also produced by most contractile cells and is upregulated during sepsis and ischemia. Three distinct receptors have the ability to bind ADM and are designated ADM receptor (also designated L1), RDC-1 and the Calcitonin Receptor-Like Receptor (CRLR). The CRLR associates with receptor activity-modifying proteins (RAMPs), which determine the specificity of CRLR binding. Co-expression with RAMP1 results in CRLR binding to CGRP, whereas association with RAMP2 or 3 results in ADM binding. The ADM receptor, a seven transmembrane G protein-coupled receptor, specifically binds ADM and is highly expressed in heart, brain, skeletal muscle, the immune system, adrenal gland and liver. The ADM receptor mediates the signals produced by ADM through G proteins, which activate adenylate cyclase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GPR182
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 2.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene GPR182
Gene Accession No. O15218, P43142
Gene Alias 7TMR; ADMR; adrenomedullin receptor; AMR; AM-R; G protein-coupled receptor 182; G10D; G10-D; gamrh; Gpcr17; Gpcr22; GPR182; G-protein coupled receptor 182; HAMR; hrhAMR; MB10; NOW; RAMR
Gene Symbols GPR182
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues near the N terminal of human G protein-coupled receptor 182.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11318, 11536
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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