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GPR26 Mouse anti-Human, Mouse, Rat, Clone: OTI3D10, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF811750

Encompass_Preferred

Catalog No. 50-167-0824


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR26 is a brain-specific orphan GPCR with a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. In the CNS, the highest GPR26 expression is in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. GPR26 is down-regulated in glioblastoma. Depletion of GPR26 has been shown to increase fat storage in C. elegans, whereas GPR26 deficiency in the hypothalamus is associated with high genetic susceptibility to the onset of obesity in mice. GPR26 deficiency also causes metabolic complications commonly associated with obesity, including glucose intolerance, hyperinsulinemia, and dyslipidemia.
Specifications

Specifications

GPR26
Monoclonal
Unconjugated
GPR26
G protein-coupled receptor 26
Mouse
Affinity Chromatography
RUO
192153, 233919, 2849
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot
OTI3D10
PBS with 8% trehalose and no preservative; pH 7.3
Q8BZA7, Q8NDV2, Q9QXI3
Gpr26
Synthetic peptide
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG2b
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