GPR26 Mouse anti-Human, Mouse, Rat, Clone: OTI3D10, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF811750

Catalog No. 50-167-0824

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR26 is a brain-specific orphan GPCR with a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. In the CNS, the highest GPR26 expression is in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. GPR26 is down-regulated in glioblastoma. Depletion of GPR26 has been shown to increase fat storage in C. elegans, whereas GPR26 deficiency in the hypothalamus is associated with high genetic susceptibility to the onset of obesity in mice. GPR26 deficiency also causes metabolic complications commonly associated with obesity, including glucose intolerance, hyperinsulinemia, and dyslipidemia.

Specifications

• Antigen: GPR26
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: GPR26
• Gene Alias: G protein-coupled receptor 26
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 192153, 233919, 2849
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI3D10
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q8BZA7, Q8NDV2, Q9QXI3
• Gene Symbols: Gpr26
• Immunogen: Synthetic peptide
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2b