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Invitrogen™ GPR26 Polyclonal Antibody
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Catalog No. PIPA532819
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50 μg
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PIPA532819 50 μg
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Catalog No. PIPA532819 Supplier Invitrogen™ Supplier No. PA532819
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Description

Rabbit Polyclonal Antibody

Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Bovine, Dog, Elephant, Panda, Horse (100%); Mouse, Rat, Rabbit, Pig (91%); Stickleback (82%). Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR26 is a brain-specific orphan GPCR with a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. In the CNS, the highest GPR26 expression is in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. GPR26 is down-regulated in glioblastoma. Depletion of GPR26 has been shown to increase fat storage in C. elegans, whereas GPR26 deficiency in the hypothalamus is associated with high genetic susceptibility to the onset of obesity in mice. GPR26 deficiency also causes metabolic complications commonly associated with obesity, including glucose intolerance, hyperinsulinemia, and dyslipidemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GPR26
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene Gpr26
Gene Accession No. Q8NDV2
Gene Alias 9630036A11Rik; A730021D22; DKFZp761H2121; FLJ33774; G protein-coupled receptor 26; Gpr26; G-protein coupled receptor 26; MGC138216; probable G-protein coupled receptor 26
Gene Symbols Gpr26
Host Species Rabbit
Immunogen Synthetic 11 amino acid peptide from internal region of human GPR26.
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100057676, 2849, 486926, 617411
Target Species Human, Canine, Monkey, Bovine, Horse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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