GPR26 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-2946	100 μL

Catalog No. 50-198-2946 Supplier Bioss Supplier No. BS13527R

Description

Rabbit Polyclonal Antibody

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR26 is a brain-specific orphan GPCR with a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. In the CNS, the highest GPR26 expression is in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. GPR26 is down-regulated in glioblastoma. Depletion of GPR26 has been shown to increase fat storage in C. elegans, whereas GPR26 deficiency in the hypothalamus is associated with high genetic susceptibility to the onset of obesity in mice. GPR26 deficiency also causes metabolic complications commonly associated with obesity, including glucose intolerance, hyperinsulinemia, and dyslipidemia.

Specifications

• Antigen: GPR26
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: Gpr26
• Gene Accession No.: Q8NDV2
• Gene Alias: 9630036A11Rik; A730021D22; DKFZp761H2121; FLJ33774; G protein-coupled receptor 26; Gpr26; G-protein coupled receptor 26; MGC138216; probable G-protein coupled receptor 26
• Gene Symbols: Gpr26
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human G protein-coupled receptor 26.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2849
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG