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GPR26 Rabbit anti-Human, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS13527R

Catalog No. 50-198-2946


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Description

Description

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR26 is a brain-specific orphan GPCR with a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. In the CNS, the highest GPR26 expression is in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. GPR26 is down-regulated in glioblastoma. Depletion of GPR26 has been shown to increase fat storage in C. elegans, whereas GPR26 deficiency in the hypothalamus is associated with high genetic susceptibility to the onset of obesity in mice. GPR26 deficiency also causes metabolic complications commonly associated with obesity, including glucose intolerance, hyperinsulinemia, and dyslipidemia.
Specifications

Specifications

GPR26
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Gpr26
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
2849
Gpr26
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Q8NDV2
9630036A11Rik; A730021D22; DKFZp761H2121; FLJ33774; G protein-coupled receptor 26; Gpr26; G-protein coupled receptor 26; MGC138216; probable G-protein coupled receptor 26
KLH conjugated synthetic peptide derived from human G protein-coupled receptor 26.
Protein A
RUO
Antibody
Polyclonal
Human
SDS
Documents
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