Invitrogen™ GPR31 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA533692

Catalog No. PIPA533692

Description

Percent identity with other species by BLAST analysis: Human, Gorilla (100%).

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding leads to activation of MAPK and NF-kappa-B pathways.

Specifications

• Antigen: GPR31
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GPR31
• Gene Alias: 12-(S)-HETE acid receptor; 12-(S)-HETE receptor; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; 12-HETER; bA517H2.2 (G protein-coupled receptor 31); G protein-coupled receptor 31; GPR31; G-protein coupled receptor 31; HETER; HETER1; hydroxyeicosatetraenoic (HETE) acid receptor 1; probable G-protein coupled receptor 31; TCP10C
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2853
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: O00270
• Gene Symbols: GPR31
• Immunogen: Synthetic 19 amino acid peptide from 2nd extracellular domain of human GPR31.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov