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Invitrogen™ GPR55 Polyclonal Antibody
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Catalog No. PIPA533735
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PIPA533735 50 μg
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Catalog No. PIPA533735 Supplier Invitrogen™ Supplier No. PA533735
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Description

Rabbit Polyclonal Antibody

Percent identity with other species by BLAST analysis: Human, Gorilla (100%) Gibbon, Monkey, Marmoset (95%) Dog, Bovine, Elephant, Panda (85%) Mouse, Horse, Pig (80%).

GPR55 has been reported to be expressed in the brain, where mRNA transcripts were detected in the caudate nucleus and putamen, but not in five other brain regions (Sawzdargo et al., 1999). ESTs have been isolated from liver/spleen libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more thana thousandmembers currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Twoblockbuster drugs which have been developed as GPCR-targetedpharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GPR55
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene GPR55
Gene Accession No. Q9Y2T6
Gene Alias G protein-coupled receptor 55; Gm218; GPCR55; GPR55; G-protein coupled receptor 55; Lpir1
Gene Symbols GPR55
Host Species Rabbit
Immunogen Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human GPR55.
Purification Method Antigen Affinity Chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9290
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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