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Invitrogen™ GPR68 Polyclonal Antibody
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Catalog No. 01674848
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100 μg
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Catalog No. Quantity
01-674-848 100 μg
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Catalog No. 01-674-848 Supplier Invitrogen™ Supplier No. PA112713
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Description

Rabbit Polyclonal Antibody

Western blot should be visualized using a high sensitivity secondary/substrate system (i.e SuperSignal West Femto Maximum Sensitivity Substrate). A suggested positive control for this product is OGR1 transfected cell lysate.

GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GPR68
Applications Immunohistochemistry, Neutralization, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.08% sodium azide
Gene GPR68
Gene Accession No. Q15743
Gene Alias BB131428; Brgr1; Brgrb; G protein-coupled receptor 68; GPR12A; Gpr68; G-protein coupled receptor 68; Ogr1; OGR-1; ovarian cancer G protein-coupled receptor, 1; ovarian cancer G-protein coupled receptor 1; Sphingosylphosphorylcholine receptor
Gene Symbols GPR68
Host Species Rabbit
Immunogen Recombinant protein corresponding to human OGR1 (GPR68) protein.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8111
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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