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Invitrogen™ GPR68 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA112713

Catalog No. 01-674-848


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Description

Description

Western blot should be visualized using a high sensitivity secondary/substrate system (i.e SuperSignal West Femto Maximum Sensitivity Substrate). A suggested positive control for this product is OGR1 transfected cell lysate.

GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

GPR68
Polyclonal
Unconjugated
GPR68
BB131428; Brgr1; Brgrb; G protein-coupled receptor 68; GPR12A; Gpr68; G-protein coupled receptor 68; Ogr1; OGR-1; ovarian cancer G protein-coupled receptor, 1; ovarian cancer G-protein coupled receptor 1; Sphingosylphosphorylcholine receptor
Rabbit
Protein A/G
RUO
8111
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Immunohistochemistry, Neutralization, Western Blot
1 mg/mL
PBS with 0.08% sodium azide
Q15743
GPR68
Recombinant protein corresponding to human OGR1 (GPR68) protein.
100 μg
Primary
Human
Antibody
IgG
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