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Invitrogen™ GPRC6A Polyclonal Antibody
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Catalog No. PIPA5102095
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100 μL
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PIPA5102095 100 μL
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Catalog No. PIPA5102095 Supplier Invitrogen™ Supplier No. PA5102095
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total GPRC6A.

GPRC6A is an Orphan-U GPCR with an unknown ligand. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more thana thousandmembers currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Twoblockbuster drugs which have been developed as GPCR-targetedpharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
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Specifications

Antigen GPRC6A
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene GPRC6A
Gene Accession No. Q5T6X5
Gene Alias bA86F4.3; G protein-coupled receptor class C group 6 member A; G protein-coupled receptor, class C, group 6, member A; G protein-coupled receptor, family C, group 6, member A; GPCR; Gprc6a; G-protein coupled receptor family C group 6 member A; G-protein coupled receptor GPCR33; hGPCR33; hGPRC6A; predicted with SOSUI analysis; seven transmembrane helix receptor
Gene Symbols GPRC6A
Host Species Rabbit
Immunogen A synthesized peptide derived from human GPRC6A(Accession Q5T6X5), corresponding to amino acid residues P504-T554.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 222545
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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