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Invitrogen™ GPS2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA566932
Description
Immunogen sequence: VHGHFQPTQTG FLQPGGALSL QKQMEHANQQ TGFSDSSSLR PMHPQALHPA PGLLASPQLP VQMQPAGKSG FAATSQPGPR LPFIQHSQNP RFYHK Highest antigen sequence identity to the following orthologs - mouse 94%, rat 95%.
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.
Specifications
GPS2 | |
Polyclonal | |
Unconjugated | |
GPS2 | |
AI505953; AMF-1; G protein pathway suppressor 2; GPS2; GPS-2 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
2874 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Immunocytochemistry | |
0.4 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q13227 | |
GPS2 | |
Recombinant Human CSN2. Recombinant protein control fragment (Product #RP-107585). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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