Invitrogen™ GPX3 Polyclonal Antibody

Catalog No.	Quantity
01-670-533	100 μL

Catalog No. 01-670-533 Supplier Invitrogen™ Supplier No. PA118280

Description

Rabbit Polyclonal Antibody

Reconstitute in 100 μL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles.

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site (4-5).

Specifications

• Antigen: GPX3
• Applications: Immunohistochemistry (Frozen)
• Classification: Polyclonal
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: whole serum with no preservative
• Gene: Gpx3
• Gene Accession No.: P22352, P23764
• Gene Alias: AA960521; EGPx; extracellular glutathione peroxidase; extracellular GPx; glutathione peroxidase 3; glutathione peroxidase 3 (plasma); GPx; Gpx3; GPx-3; Gpxp; GPx-P; GSHPx-3; GSHPx-P; plasma form; plasma glutathione peroxidase; plasma GPx
• Gene Symbols: Gpx3
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to residues F(135) E K G D V N G E K E Q K F Y T F L K N(154) of human glutathione peroxidase 3 (GPx-P) conjugated to diptheria toxin.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2878, 64317
• Target Species: Human, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov