Invitrogen™ Gpx3 Polyclonal Antibody

Catalog No.	Quantity
PIPA518677	100 μg

Catalog No. PIPA518677 Supplier Invitrogen™ Supplier No. PA518677

Description

Goat Polyclonal Antibody

This antibody is predicted to react with canine, human and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site (4-5).

Specifications

• Antigen: Gpx3
• Applications: Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene: Gpx3
• Gene Accession No.: P22352, P46412
• Gene Alias: AA960521; EGPx; extracellular glutathione peroxidase; extracellular GPx; glutathione peroxidase 3; glutathione peroxidase 3 (plasma); GPx; Gpx3; GPx-3; Gpxp; GPx-P; GSHPx-3; GSHPx-P; plasma form; plasma glutathione peroxidase; plasma GPx
• Gene Symbols: Gpx3
• Host Species: Goat
• Immunogen: Synthetic peptide sequence (NQFGKQEPGENSE) corresponding to the internal amino acids of GPX3 (aa 102-114).
• Purification Method: Ammonium sulfate precipitation, Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 14778, 2878
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

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