Invitrogen™ GPX3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120190

Catalog No. PIPA5120190

Description

Positive test controls include: HepG2, Mouse kidney, Mouse liver. The target is usually found in the following locations: Secreted. Immunogen sequence: QSRGQEKSKM DCHGGISG.

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site (4-5).

Specifications

• Antigen: GPX3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gpx3
• Gene Alias: AA960521; EGPx; extracellular glutathione peroxidase; extracellular GPx; glutathione peroxidase 3; glutathione peroxidase 3 (plasma); GPx; Gpx3; GPx-3; Gpxp; GPx-P; GSHPx-3; GSHPx-P; plasma form; plasma glutathione peroxidase; plasma GPx
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14778, 2878, 64317
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.14 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: P22352, P23764, P46412
• Gene Symbols: Gpx3
• Immunogen: Synthetic peptide.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG