Invitrogen™ GPX3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522969

Catalog No. PIPA522969

Description

The target sequence has 89% sequence homology with mouse, 88% sequence homology with bovine and 84% sequence homology with porcine. Suggested positive control: HeLa whole cell extract.

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site (4-5).

Specifications

• Antigen: GPX3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gpx3
• Gene Alias: AA960521; EGPx; extracellular glutathione peroxidase; extracellular GPx; glutathione peroxidase 3; glutathione peroxidase 3 (plasma); GPx; Gpx3; GPx-3; Gpxp; GPx-P; GSHPx-3; GSHPx-P; plasma form; plasma glutathione peroxidase; plasma GPx
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat, Monkey
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: Conc. Not Determined
• Formulation: Whole serum with 0.1% sodium azide
• Gene Accession No.: P22352, P23764
• Gene Symbols: Gpx3
• Immunogen: Full length human GPX3 protein expressed in E. coli.
• Regulatory Status: RUO
• Gene ID (Entrez): 2878, 64317
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov