Invitrogen™ GRAMD4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA598543

Catalog No. PIPA598543

Description

GRAMD4 Polyclonal Antibody for Western Blot, IHC (P), ELISA

GRAMD4 also termed as Death inducing protein is a 578 amino-acid protein, which contains 1 GRAM domain. GRAMD4 as a multi-pass membrane protein localizes in the Mitochondrion membrane. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly (ADP-ribose)-polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows up-regulation in mitochondria by E2F-1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies.

Specifications

• Antigen: GRAMD4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GRAMD4
• Gene Alias: 9930016O13; dA59H18.1; death-inducing protein; death-inducing-protein; DIP; dJ439F8.1; GRAM domain containing 4; GRAM domain-containing protein 4; GRAM domain-containing protein 4 (GRAMD4); Gramd4; Kiaa0767
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 223752, 23151
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 5 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: Q6IC98, Q8CB44
• Gene Symbols: GRAMD4
• Immunogen: Recombinant Human GRAM domain-containing protein 4 protein (23-161AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov