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Epredia™ Lab Vision™ Granzyme B Ab-1, Mouse Monoclonal Antibody

Catalog No. MS1157S1 Shop All Epredia Products
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100 μL
500 μL
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7 mL
12 mL
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Catalog No. Quantity Form
MS1157S1 500 μL Concentrated
MS1157S 1 mL Concentrated
MS1157S0 100 μL Concentrated
MS1157R1 1 mL Prediluted
MS1157R7 7 mL Prediluted
MS1157RQ 12 mL Ready-to-Use
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Description

Ensure accurate, reproducible results in immunohistochemistry experiments with Epredia™ Granzyme B Ab-1, Mouse Monoclonal Antibody.

Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified. One of these, human granzyme B, is involved in target cell apoptosis during lymphocyte-mediated cytotoxicity. Exocytosis of granzyme-containing granules in the cytoplasm of the target cell leads to the induction of DNA fragmentation and apoptosis.

Host Species: Mouse

Clone: GZB01

Isotype: IgG2a

Species Reactivity: Human. Others not known.

Epitope: N-terminal

Immunogen: Recombinant protein encoding the N-terminus of the mature granzyme B

Molecular Weight: 32 kDa

Positive Control: Hodgkin's lymphoma, Tonsil

Cellular Localization: Granular cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin only)

Specifications

Antigen Granzyme B Ab-1
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone GZB01
Conjugate Unconjugated
Host Species Mouse
Immunogen Recombinant protein encoding the N-terminus of the mature granzyme B
Purification Method Hodgkin's lymphoma
Quantity 500 μL
Regulatory Status IVD
Research Discipline Apoptosis
Primary or Secondary Primary
Target Species Human
Form Concentrated
Isotype IgG2a
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