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Granzyme B Mouse, anti-Human, R718, Clone: GB11, BD Horizon™

Catalog No. BDB566964 Shop All BD Biosciences Products
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BDB566964 100 μg
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Catalog No. BDB566964 Supplier BD Biosciences Supplier No. 566964
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Description

Mouse Monoclonal Antibody

The GB11 antibody specifically reacts with human granzyme B, a serine protease of approximately 32 kDa. Granzyme B is stored in the granules of cytotoxic T lymphocytes and NK cells along with the pore-forming protein perforin. In the classic model of target cell lysis, perforins create holes in the target cell membrane allowing entrance of granzymes. Granzyme B has been shown to act on specific substrates including caspase-3, -7, -9, and -10 which in turn give rise to enzymes that mediate apoptosis. Granzyme B may also be involved in the hydrolysis of extracellular matrix components. Detectable levels of granzyme B have been detected in sera from healthy volunteers. The immunogen used to generate the GB11 hybridoma was human granzyme B isolated from an NK cell line.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Granzyme B
Applications Flow Cytometry
Classification Monoclonal
Clone GB11
Conjugate R718
Host Species Mouse
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Refrigerate Upon Arrival
Form Liquid
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