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Granzyme B Mouse, anti-Human, R718, Clone: GB11, BD Horizon™

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 566964

Catalog No. BDB566964


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Description

Description

The GB11 antibody specifically reacts with human granzyme B, a serine protease of approximately 32 kDa. Granzyme B is stored in the granules of cytotoxic T lymphocytes and NK cells along with the pore-forming protein perforin. In the classic model of target cell lysis, perforins create holes in the target cell membrane allowing entrance of granzymes. Granzyme B has been shown to act on specific substrates including caspase-3, -7, -9, and -10 which in turn give rise to enzymes that mediate apoptosis. Granzyme B may also be involved in the hydrolysis of extracellular matrix components. Detectable levels of granzyme B have been detected in sera from healthy volunteers. The immunogen used to generate the GB11 hybridoma was human granzyme B isolated from an NK cell line.

Specifications

Specifications

Granzyme B
GB11
Liquid
100 μg
Refrigerate Upon Arrival
Monoclonal
Flow Cytometry
R718
Mouse
RUO
Primary
Human
SDS
Documents
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