Invitrogen™ Granzyme K Monoclonal Antibody (C8), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA551116

Catalog No. FEMA551116

Description

Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.

Specifications

• Antigen: Granzyme K
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
• Gene Accession No.: O35205, P49864
• Gene Symbols: GZMK
• Immunogen: Recombinant Mouse GZMK protein, Gln44-Val227 (Accession #O35205).
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2b κ

• Applications: Western Blot
• Clone: C8
• Conjugate: Unconjugated
• Gene: GZMK
• Gene Alias: Fragmentin-3; granzyme 3; granzyme K; granzyme K (granzyme 3; tryptase II); granzyme K (serine protease, granzyme 3; tryptase II); granzyme-3; GrK; GZMK; NK-Tryp-2; NK-tryptase-2; RNK-Tryp-2; TRYP2; tryptase II
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 14945, 29165
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid