Granzyme K Monoclonal Antibody (GM24C3), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA117753

Catalog No. 01-670-166

Description

This antibody recognizes native Granzyme K protein expressed in transfected mammalian cells.

Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.

Specifications

• Antigen: Granzyme K
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: GZMK
• Gene Alias: Fragmentin-3; granzyme 3; granzyme K; granzyme K (granzyme 3; tryptase II); granzyme K (serine protease, granzyme 3; tryptase II); granzyme-3; GrK; GZMK; NK-Tryp-2; NK-tryptase-2; RNK-Tryp-2; TRYP2; tryptase II
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 3003
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Flow Cytometry
• Clone: GM24C3
• Formulation: PBS with no preservative; pH 7.2
• Gene Accession No.: P49863
• Gene Symbols: GZMK
• Immunogen: cDNA encoding human Granzyme K
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

Safety and Handling

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