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Invitrogen™ Granzyme K Polyclonal Antibody

Catalog No. PIPA587719
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Catalog No. Quantity
PIPA587719 100 μL
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Catalog No. PIPA587719 Supplier Invitrogen™ Supplier No. PA587719

Description

Rabbit Polyclonal Antibody

Immunogen sequence: IIGGKEVSPH SRPFMASIQY GGHHVCGGVL IDPQWVLTAA HCQYRFTKGQ SPTVVLGAHS LSKNEASKQT LEIKKFIPFS RVTSDPQSND IMLVKLQTAA KLNKHVKMLH IRSKTSLRSG TKCKVTGWGA TDPDSLRPSD TLREVTVTVL SRKLCNSQSY YNGDPFITKD MVCAGDAKGQ KDSCKGDSGG PLICKGVFHA IVSGGHECGV ATKPGIYTLL TKKYQTWIKS NLVPPHTN; Positive Samples: Mouse liver, Rat liver; Cellular Location: Cytoplasmic granule.

Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Granzyme K
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.06 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene GZMK
Gene Accession No. O35205, P49864
Gene Alias Fragmentin-3; granzyme 3; granzyme K; granzyme K (granzyme 3; tryptase II); granzyme K (serine protease, granzyme 3; tryptase II); granzyme-3; GrK; GZMK; NK-Tryp-2; NK-tryptase-2; RNK-Tryp-2; TRYP2; tryptase II
Gene Symbols GZMK
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 27-264 of human GZMK (NP_0020951).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14945, 29165
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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