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Invitrogen™ Granzyme M Monoclonal Antibody (4B2G4), eFluor™ 660, eBioscience™
Mouse Monoclonal Antibody
$500.00
Specifications
Antigen | Granzyme M |
---|---|
Clone | 4B2G4 |
Concentration | 5 μL/Test |
Content And Storage | 4°C, store in dark, DO NOT FREEZE! |
Applications | Flow Cytometry |
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
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Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-112-4542
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Invitrogen™
50977442 |
100 Tests |
Each of 1 for $500.00
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Description
Description: Granzyme M is one of five granzyme serine proteases that have been identified in humans. These proteins are expressed in the granules of NK cells and cytotoxic T cells, and are critical for the induction of target cell apoptosis through the cleavage of intracellular substrates. Although not as well characterized as some of the other family members, Granzyme M has been found to exhibit some distinct functions. These include the non-cytotoxic inhibition of cytomegalovirus replication, induction of apoptosis in tumor cells, and contribution to the TLR4-induced inflammatory process. Applications Reported: This 4B2G4 antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This 4B2G4 antibody has been pre-titrated and tested by intracellular staining followed by flow cytometric analysis of normal human peripheral blood cells using the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00) and protocol. Please refer to BestProtocols®: Protocol A: Two step protocol for (cytoplasmic) intracellular proteins located under the Resources Tab online. This can be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at...
Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.Specifications
Granzyme M | |
5 μL/Test | |
Flow Cytometry | |
eFluor 660 | |
Mouse | |
RUO | |
PBS with BSA and 0.09% sodium azide; pH 7.2 | |
P51124 | |
3004 | |
Primary | |
Affinity Chromatography |
4B2G4 | |
4°C, store in dark, DO NOT FREEZE! | |
Monoclonal | |
Liquid | |
IgG1 κ | |
Human | |
GZMM | |
granzyme M; granzyme M (lymphocyte met-ase 1); GZMM; Hu-Met-1; Lmet1; lymphoctye Met-ase 1; lymphocyte met-ase 1; MET1; Met-1 serine protease; Met-ase; MMET-1; natural killer cell granular protease; RNK-Met-1 | |
GZMM | |
Antibody |
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