Invitrogen™ GRASP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534893

Catalog No. PIPA534893

Description

Recommended positive controls: NT2D1, PC-3, SK-N-SH, mouse brain. Predicted reactivity: Mouse (87%), Rat (87%), Bovine (91%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo (Scannevin and Huganir, 2000). Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity (Ye et al., 2000).

Specifications

• Antigen: GRASP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GRIPAP1
• Gene Alias: 30kDa C-terminus form; AI854681; DXImx47e; Grasp1; GRASP-1; GRASP-1 C-terminal chain; GRIP1; GRIP-1; GRIP1 associated protein 1; GRIP1-associated protein 1; Gripap1; GRIP-associated protein 1; HCMV-interacting protein; Kiaa1167; mKIAA1167; MPMGp800B12492Q3; Sfc10
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54645, 56850
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q4V328, Q8VD04
• Gene Symbols: GRIPAP1
• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human GRASP1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG