Invitrogen™ GRB10 Monoclonal Antibody (5H7)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA549206

Catalog No. PIMA549206

Description

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human Hek293 whole cell, human Hela whole cell, monkey COS-7 whole cell, human HepG2 whole cell, rat kidney tissue, rat NRK whole cell. Flow: THP-1 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP, and a proline-rich N terminus. A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7. GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly. GRB10 maps to mouse chromosome 11, in close proximity to the EGF receptor. Similarly, GRB7 maps to the same mouse chromosome near the EGF receptor-related protein HER2.

Specifications

• Antigen: GRB10
• Classification: Monoclonal
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and no preservative
• Gene Accession No.: P0CE43, Q13322
• Gene Symbols: GRB10
• Immunogen: E.coli-derived human GRB10 recombinant protein (Position: M1-K251).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat, Monkey
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Western Blot
• Clone: 5H7
• Conjugate: Unconjugated
• Gene: GRB10
• Gene Alias: 5730571D09Rik; AI325020; Grb10; Grb-10; GRB10 adapter protein; GRB10 adaptor protein; GRBIR; GRB-IR; growth factor receptor bound protein 10; growth factor receptor-bound protein 10; Insulin receptor-binding protein Grb-IR; IRBP; KIAA0207; maternally expressed gene 1; maternally expressed gene 1 protein; Meg1; mKIAA0207; OTTHUMP00000197988; OTTHUMP00000197989; OTTHUMP00000197990; OTTHUMP00000197991; OTTHUMP00000197993; OTTHUMP00000197994; RGD1566234; RSS
• Host Species: Mouse
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2887, 498416
• Content And Storage: -20°C
• Form: Lyophilized