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Invitrogen™ GRID2 Polyclonal Antibody
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Catalog No. PIPA5115325
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PIPA5115325 100 μL
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Catalog No. PIPA5115325 Supplier Invitrogen™ Supplier No. PA5115325
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total GRID2.

GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GRID2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene GRID2
Gene Accession No. O43424, Q61625, Q63226
Gene Alias B230104L07Rik; cpr; creeper; GluD2; gluR delta-2 subunit; GLURD2; GluRdelta2; glutamate ionotropic receptor delta type subunit 2; glutamate receptor; glutamate receptor delta-2 subunit; glutamate receptor ionotropic, delta-2; glutamate receptor, ionotropic, delta 2; Grid2; ho; hotfoot; Lc; Lc>J>; lurcher; minisatellite 10ac detected by probe MMS10; MMS10-AC; Ms10ac; nmf408; SCAR18; tpr
Gene Symbols GRID2
Host Species Rabbit
Immunogen A synthesized peptide derived from human GRID2(Accession O43424), corresponding to amino acid residues A840-S890.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14804, 2895, 79220
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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