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Invitrogen™ GRIK1 Polyclonal Antibody
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Catalog No. PIPA518789
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100 μg
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Catalog No. Quantity
PIPA518789 100 μg
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Catalog No. PIPA518789 Supplier Invitrogen™ Supplier No. PA518789
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Description

Goat Polyclonal Antibody

This antibody is predicted to react with mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GRIK1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Grik1
Gene Accession No. P39086
Gene Alias A830007B11Rik; D16Ium24; D16Ium24e; EAA3; EEA3; excitatory amino acid receptor 3; GLR5; GluK1; GluK5; GLUR5; gluR-5; Glurbeta1; glutamate ionotropic receptor kainate type subunit 1; glutamate receptor; glutamate receptor 5; Glutamate receptor ionotropic, kainate 1; glutamate receptor subunit 5; glutamate receptor, ionotropic, kainate 1; GRIK1
Gene Symbols Grik1
Host Species Goat
Immunogen Synthetic peptide sequence (QCKQTHPTNSTS) corresponding to the internal amino acids of GRIK1 (aa 878-890).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2897
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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