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Invitrogen™ GRIP1 Polyclonal Antibody
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Catalog No. PIPA578570
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PIPA578570 100 μL
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Catalog No. PIPA578570 Supplier Invitrogen™ Supplier No. PA578570
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Description

Rabbit Polyclonal Antibody

Predicted Reactivity: Human (100%), Zebrafish (82%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Glucocorticoid receptor interacting protein-1 (GRIP1), or Transcription Intermediary Factor 2 (TIF2), is a member of a family of transcriptional coactivator proteins which includes steroid receptor coactivator-1 (SRC-1) and Amplified in breast cancer-1 (AIB-1). GRIP1 has been shown to interact and stimulate transcriptional activity of the retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, estrogen, progesterone, and peroxisome proliferator activated receptors. GRIP1 also contains several copies of the conserved LXXLL/LLXXL motif which has been demonstrated to be critical to receptor-coactivator interactions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GRIP1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.54 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene GRIP1
Gene Accession No. P97879, Q925T6, Q9Y3R0
Gene Alias 4931400F03Rik; AMPA receptor-interacting protein GRIP1; eb; eye blebs; glutamate receptor interacting protein 1; glutamate receptor-interacting protein 1; GRIP; Grip1; GRIP-1
Gene Symbols GRIP1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human GRIP1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23426, 74053, 84016
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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