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Invitrogen™ GRIP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578570

Catalog No. PIPA578570


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Description

Description

Predicted Reactivity: Human (100%), Zebrafish (82%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Glucocorticoid receptor interacting protein-1 (GRIP1), or Transcription Intermediary Factor 2 (TIF2), is a member of a family of transcriptional coactivator proteins which includes steroid receptor coactivator-1 (SRC-1) and Amplified in breast cancer-1 (AIB-1). GRIP1 has been shown to interact and stimulate transcriptional activity of the retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, estrogen, progesterone, and peroxisome proliferator activated receptors. GRIP1 also contains several copies of the conserved LXXLL/LLXXL motif which has been demonstrated to be critical to receptor-coactivator interactions.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

GRIP1
Polyclonal
Unconjugated
GRIP1
4931400F03Rik; AMPA receptor-interacting protein GRIP1; eb; eye blebs; glutamate receptor interacting protein 1; glutamate receptor-interacting protein 1; GRIP; Grip1; GRIP-1
Rabbit
Antigen Affinity Chromatography
RUO
23426, 74053, 84016
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Immunocytochemistry
0.54 mg/mL
0.1M tris glycine with 20% glycerol, 0.1M glycine and 0.01% thimerosal; pH 7
P97879, Q925T6, Q9Y3R0
GRIP1
Recombinant protein encompassing a sequence within the center region of human GRIP1. The exact sequence is proprietary.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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