Invitrogen™ GRK7 Polyclonal Antibody

Catalog No.	Quantity
PIPA5140213	100 μL

Catalog No. PIPA5140213 Supplier Invitrogen™ Supplier No. PA5140213

Description

Rabbit Polyclonal Antibody

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: EEGPTKDSAL QGLVATCASA PAPGNPQPFL SQAVATKCQA ATTEEERVAA VTLAKAEAMA FLQEQPFKDF VTSAFYDKFL QWKLFEMQPV SD Highest antigen sequence indentity to the following orthologs: Rat - 27%, Mouse - 28%.

GRK7 is a serine/threonine kinase that is specifically expressed in the retina and phosphorylates cone opsins and initiates their deactivation. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Specifications

• Antigen: GRK7
• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.05 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: GRK7
• Gene Accession No.: Q8WTQ7
• Gene Alias: G protein-coupled receptor kinase 7; g protein-coupled receptor kinase GRK7; GPRK7; GRK7; rhodopsin kinase; Rhodopsin kinase GRK7
• Gene Symbols: GRK7
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human GRK7. Recombinant protein control fragment (Product #RP-98391).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 131890
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG