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Invitrogen™ GRK7 Polyclonal Antibody
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Catalog No. PIPA5101218
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100 μL
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PIPA5101218 100 μL
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Catalog No. PIPA5101218 Supplier Invitrogen™ Supplier No. PA5101218
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total GRK7.

GRK7 is a serine/threonine kinase that is specifically expressed in the retina and phosphorylates cone opsins and initiates their deactivation. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
TRUSTED_SUSTAINABILITY

Specifications

Antigen GRK7
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene GRK7
Gene Accession No. Q8WTQ7
Gene Alias G protein-coupled receptor kinase 7; g protein-coupled receptor kinase GRK7; GPRK7; GRK7; rhodopsin kinase; Rhodopsin kinase GRK7
Gene Symbols GRK7
Host Species Rabbit
Immunogen A synthesized peptide derived from human GRK7(Accession Q8WTQ7), corresponding to amino acid residues P371-E421.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 131890
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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