GRM2 Mouse anti-Human, Clone:4A10B9, Abnova™

Mouse monoclonal antibody raised against partial recombinant human GRM2.

Supplier:  Abnova Corporation MAB17966

Catalog No. 89-334-319

Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Specifications

• Antigen: GRM2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:10000)
  Flow Cytometry (1:200-1:400)
  Western Blot (1:100-1:500)
  The optimal working dilution should be determined by the end user.
• Gene: GRM2
• Host Species: Mouse
• Quantity: 100 μg
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Western Blot
• Clone: 4A10B9
• Description: glutamate receptor, metabotropic 2
• Formulation: In PBS (0.05% sodium azide)
• Gene Alias: GLUR2, GPRC1B, MGLUR2, mGlu2
• Immunogen: Recombinant protein corresponding to amino acids 414-558 of human GRM2.
• Gene ID (Entrez): 2912
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid