GRM3 Mouse anti-Human, Clone:6H10C3, Abnova™

Catalog No.	Quantity
89-334-008	100 μg

Catalog No. 89-334-008 Supplier Abnova Corporation Supplier No. MAB17542

Description

Mouse monoclonal antibody raised against recombinant human GRM3.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq]

Specifications

• Antigen: GRM3
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 6H10C3
• Conjugate: Unconjugated
• Description: glutamate receptor, metabotropic 3
• Dilution: ELISA (1:10000)
  Western Blot (1:500-1:2000)
  Immunocytochemistry
  Flow Cytometry (1:200-1:400)
  Immunohistochemistry (1:200-1:1000)
  The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.05% sodium azide)
• Gene: GRM3
• Gene Alias: GLUR3, GPRC1C, MGLUR3, mGlu3
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acid 433-576 of human GRM3 from E. coli.
• Quantity: 100 μg
• Gene ID (Entrez): 2913
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1