GRM8 Mouse anti-Human, Clone:4C1C1, Abnova™

Mouse monoclonal antibody raised against recombinant human GRM8.

Supplier:  Abnova Corporation MAB17637

Catalog No. 89-333-939

Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]

Specifications

• Antigen: GRM8
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:10000)
  Western Blot (1:500-1:2000)
  Immunocytochemistry
  Flow Cytometry (1:200-1:400)
  Immunohistochemistry
  The optimal working dilution should be determined by the end user.
• Gene: GRM8
• Host Species: Mouse
• Quantity: 100 μg
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Western Blot
• Clone: 4C1C1
• Description: glutamate receptor, metabotropic 8
• Formulation: In PBS (0.05% sodium azide)
• Gene Alias: FLJ41058, GLUR8, GPRC1H, MGC126724, MGLUR8, mGlu8
• Immunogen: Recombinant protein corresponding to amino acid 440-583 of human GRM8 from E. coli.
• Gene ID (Entrez): 2918
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid