Invitrogen™ Growth Hormone Receptor Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA565404

Catalog No. PIPA565404

Description

Immunogen sequence: NWTLLNVSLTG IHADIQVRWE APRNADIQKG WMVLEYELQY KEVNETKWKM MDPILTTSVP VYSLKVDKEY EVRVRSKQRN SGNYGEFSEV LYVTLPQMSQ F Highest antigen sequence identity to the following orthologs - mouse 66%, rat 68%.

Growth hormone receptor (GHR) is a gene located on chromosome 5p13.1, encoding a transmembrane receptor that plays a critical role in mediating the effects of growth hormone, which is crucial for growth, metabolism, and tissue development. GHR is expressed in various tissues, including the liver, muscle, and adipose tissue, and facilitates the growth hormone signaling pathway by binding to growth hormone, leading to receptor dimerization and activation of intracellular signaling cascades such as the JAK2-STAT5 pathway. This signaling promotes growth and anabolic processes, influencing body composition, insulin sensitivity, and lipid metabolism. Mutations or alterations in the GHR gene can lead to growth disorders like Laron syndrome, characterized by insensitivity to growth hormone. Understanding GHR's structure and function is pivotal for developing therapeutic strategies for growth deficiencies and metabolic syndromes, as modifying GHR signaling pathways can offer potential interventions in related conditions.

Specifications

• Antigen: Growth Hormone Receptor
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GHR
• Gene Alias: GH receptor; GH-binding protein; GHBP; GHIP; GHR; GHR/BP; growth hormone binding protein; growth hormone receptor; growth hormone receptor precursor; Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein); growth hormone receptor precursor splice variant D56; growth hormone receptor variant d5-6; growth hormone receptor/binding protein; Growth hormone-binding protein; MGC124963; MGC156665; serum binding protein; Serum-binding protein; Somatotropin receptor; unnamed protein product
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2690
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P10912
• Gene Symbols: GHR
• Immunogen: Recombinant Human Growth Hormone Receptor. Recombinant protein control fragment (Product #RP-106086).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov